Publications
With more than 70 publications and 2 patents,
Dr. Marco Bocola has
over 15 years of experience in protein engineering and design.
Patents
- New glucose oxidase comprising additional amino acid
substitution in specified positions of specified sequence,
useful for detecting, determining or measuring glucose in an ex
vivo sample e.g. blood using sensor or test strip device
M. Bocola, H. Duefel, E. Gutierrez, D. Heindl, T. Meier, H. Mundhada, U. Schwaneberg, M. Tacke
28. 1. 2014 WO2014114810-A1 CA2891285-A1 KR2015101466-A - Lipase variants
M. Matuschek, R. Stuermer, B. Hauer, G. Klebe, M. Bocola
17. 10. 2002 , EP20020782936, WO/2003/035878
Selected Publications
- Y. Ensari, G.V. Dhoke, M.D. Davari, M.
Bocola, A.J. Ruff, U. Schwaneberg
Inversion of cpADH5 Enantiopreference and Altered Chain Length Specificity for Methyl 3-Hydroxyalkanoates.
Chemistry. 2017 Jul 20. doi: 10.1002/chem.201702581 - U. Markl, L.Zhu, V. Frauenkron Machediou,
J. Zhao, M. Bocola, M.D. Davari, K.-E. Jaeger, U. Schwaneberg
Are Directed Evolution Approaches Efficient in Exploring Nature’s Potential to Stabilize a Lipase in Organic Cosolvents?
Catalysts 2017 Mai, 7(5):142 · DOI: 10.3390/catal7050142 - G. V. Dhoke, Y. Ensari, M.D. Davari, A.J. Ruff, U.
Schwaneberg, M. Bocola: What's My Substrate? Computational
Function Assignment of Candida parapsilosis ADH5 by Genome
Database Search, Virtual Screening, and QM/MM Calculations.
J Chem Inf Model. 56(7),1313-23 (2016). doi: 10.1021/acs.jcim.6b00076 - I. El-Awaad, M. Bocola, T. Beuerle, B. Liu and L. Beerhues
Bifunctional CYP81AA proteins catalyse identical hydroxylations but alternative regioselective phenol couplings in plant xanthone biosynthesis.
Nat Commun, 7, 11472 (2016) doi:10.1038/ncomms11472 - C. Lehmann, M. Bocola, W. R. Streit, R. Martinez and U.
Schwaneberg
Ionic liquid and deep eutectic solvent-activated CelA2 variants generated by directed evolution.
Applied Microbiology and Biotechnology, 98(12), 5775-5785 (2014) doi:10.1007/s00253-014-5771-y - L. Vojcic, D. Despotovic, K. H. Maurer, M. Zacharias, M.
Bocola, R. Martinez and U. Schwaneberg
Reengineering of subtilisin Carlsberg for oxidative resistance.
Biological Chemistry, 394(1), 79-87 (2013) doi:10.1515/hsz-2012-0210 - T. Gerhards, U. Mackfeld, M. Bocola, E. von Lieres, W.
Wiechert, M. Pohl and D. Rother
Influence of Organic Solvents on Enzymatic Asymmetric Carboligations.
Advanced Synthesis & Catalysis, 354(14-15), 2805-2820 (2012) doi:10.1002/adsc.201200284 - H. Guldan, F. M. Matysik, M. Bocola, R. Sterner and P.
Babinger
Functional Assignment of an Enzyme that Catalyzes the Synthesis of an Archaea-Type Ether Lipid in Bacteria.
Angewandte Chemie-International Edition, 50(35), 8188-8191 (2011) doi:10.1002/anie.201101832 - M. T. Reetz, S. Prasad, J. D. Carballeira, Y. Gumulya and M.
Bocola
Iterative Saturation Mutagenesis Accelerates Laboratory Evolution of Enzyme Stereoselectivity: Rigorous Comparison with Traditional Methods.
Journal of the American Chemical Society, 132(26), 9144-9152 (2010) doi:10.1021/ja1030479 - M. T. Reetz, M. Bocola, J. D. Carballeira, D. X. Zha and A.
Vogel
Expanding the range of substrate acceptance of enzymes: Combinatorial active-site saturation test.
Angewandte Chemie-International Edition, 44(27), 4192-4196 (2005) doi:10.1002/anie.200500767 - S. A. Funke, N. Otte, T. Eggert, M. Bocola, K. E. Jaeger and
W. Thiel
Combination of computational prescreening and experimental library construction can accelerate enzyme optimization by directed evolution.
Protein Engineering Design & Selection, 18(11), 509-514 (2005) doi:10.1093/protein/gzi062 - M. Bocola, F. Schulz, F. Leca, A. Vogel, M. W. Fraaije and
M. T. Reetz
Converting phenylacetone monooxygenase into phenylcyclohexanone monooxygenase by rational design: Towards practical Baeyer-Villiger monooxygenases.
Advanced Synthesis & Catalysis, 347(7-8), 979-986 (2005) doi:10.1002/adsc.200505069
For a full list of publications please visit ResearchGate